A 1D multifluid population balance model approach is presented as a compromise between computational effort and accuracy. The approach is used to test process scenarios, perform sensitivity analysis, and provide a reliable scale-up and optimization tool. The study focuses on a mini-plant batch bubble column, where the scale-up behavior in terms of bubble column height, gas flux, and composition of the liquid phase is investigated. Although simplifications were made, the model requires calibration to experimental data using different calibration methods. An optimal calibration procedure is found that minimizes experimental effort while maximizing scalability. The model was tested on various liquid-phase compositions, and it was found to reproduce experimental data accurately. However, the model cannot reproduce flow regime changes and does not perform well outside the calibrated concentration. The study shows that the applied 1D multifluid populations balance approach is a valuable and reliable tool in multiphase reactor scale-up and optimization.