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TH17 cell: a double-edged sword in the development of inflammatory bowel disease
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  • Ge Wang,
  • Yue Wen,
  • Han Wang,
  • De-An Tian
Ge Wang
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology

Corresponding Author:[email protected]

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Yue Wen
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
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Han Wang
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
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De-An Tian
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
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Abstract

Inflammatory bowel disease (IBD) is a chronic non-specific inflammatory disease of the gastrointestinal tract, and its pathogenesis has not been fully understood. Extensive dysregulation of the intestinal mucosal immune system is critical in the development and progression of IBD. T-helper (Th) 17 cells have the characteristics of plasticity. They can transdifferentiate into subpopulations with different functions in response to different factors in the surrounding environment, thus taking on different roles in regulating the intestinal immune response. In this review, we will focus on the plasticity of Th17 cells as well as the function of Th17 cells and related cytokines in IBD. We will summarize their pathogenic and protective roles in IBD under different conditions, respectively, hoping to further deepen the understanding of the pathological mechanism of IBD and provide ideas for the future treatment.