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Palladium-catalyzed carbonylation with direct indole C-H activation involving HCFO-1233zd (E)
  • +6
  • Xiao Zhao,
  • Wen Zhu,
  • Yu Jing,
  • Yi Shi,
  • Jin Zhang,
  • Hong Li,
  • Min Yang,
  • Qiang Fan,
  • Yang Li
Xiao Zhao
Xi’an Polytechnic University
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Wen Zhu
Xi'an Polytechnic University
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Yu Jing
Xi’an Polytechnic University
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Yi Shi
Xi’an Polytechnic University,
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Jin Zhang
Xi'an Polytechnic University
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Hong Li
Xi'an Polytechnic University
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Min Yang
Xi'an Polytechnic University
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Qiang Fan
Xi’an Polytechnic University
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Yang Li
Xi’an Polytechnic University

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Abstract

3-Idolenone is a key intermediate in the synthesis of many drugs and plays an important role in synthetic chemistry and biochemi-stry. A new method for the synthesis of trifluoromethylated 3-indolenones by carbonylation reaction catalyzed by Pd (0) is de-scribed. In the absence of an additive, 1-chloro-3,3,3-trifluoro-propylene (a cheap ozone-friendly CF3 structural unit) reacts with indole and carbon monoxide to synthesize trifluoromethylatedindolenone, good yield, Regioselectivity and Chemoselectivity, and strong resistance to basal functional groups such as alkynes, aldehydes and esters. It is worth mentioning that not only indole compounds can be well transformed into the corresponding products, pyrrole, hetero-indole also can be well completed the cor-responding chemical transformation. This late construction of trifluoromethylated indole/pyrrole 3-ketene provides a scientific method.
10 Nov 2023Submitted to Chinese Journal of Chemistry
13 Nov 2023Submission Checks Completed
13 Nov 2023Assigned to Editor
13 Nov 2023Review(s) Completed, Editorial Evaluation Pending
14 Nov 2023Reviewer(s) Assigned