To Treat or Not to Treat? Facing Spontaneous Remission of a Neonatal
Malignant Mesenchymal Spindle-Cell Neoplasia
Abstract
We report a case of malignant mesenchymal spindle-cell neoplasia of the
skull, diagnosed in a female newborn at 13 days of age by biopsy and
subtotal resection. Considering the good clinical condition, the age,
tumor histology and the risks associated with surgery and chemotherapy,
we proposed a “wait and see” approach with a close radiologic
monitoring of the tumor lesion. Surprisingly the tumor showed
spontaneous regression both at MRI and ultrasound evaluations. To date,
after 12 months of observation, MRI showed sustained remission: the
infant recovered from surgery and maintains good clinical condition
while follow-up is ongoing.