The Effect of the Immunoglobulin G- A- M Treatment on Hepatic Function
Tests in Patients with Severe Sepsis
Abstract
Purpose: To explore the effects of conventional sepsis treatment,
including classical antibiotherapy and IgG-A-M combinations, on liver
function tests in patients with severe sepsis. Material and method: Our
study retrospectively examined the effects of Immunoglobulin G-A-M
combination (Pentoglobin®) on liver function test and mortality rate in
patients who were in the septic process. We administered the
Immunoglobulin G-A-M combination infusion lasting 12 hours at a dose of
5mg/kg for three days to the patients we enrolled in the study. We
administered this protocol to a total of 70 patients who met the study
criteria. Results: Immunoglobulin G-A-M combination therapy had no
statistically significant effect on liver function tests and mortality
in sepsis. Conclusion: Sepsis is a clinical condition that continues to
have a high mortality rate despite advances in treatment modalities.
Although anti-infective And anti-inflammatory treatments are used, there
is no clear daya on their efficacy.However, early diagnosis of sepsis,
early initiation of antibiothearpy, early source control And timely
initiation of appropriate fluid therapy play a key role in succsess of
sepsis treatment. For this purpose, as emphasized in the sepsis 3
guideline, we think that raising awareness by physicians And
practitioners in early diagnosis of sepsis is the Most important step in
the treatment of this clinical condition. Keywords: sepsis, liver
function tests, immunoglobulin G-A-M