Storming the castle: A case report of multi-system dysregulation in a
child with Castleman disease
- Samantha DeMarsh,
- Nicole Kendall,
- Christine Bacha,
- Stacy Ardoin,
- Melissa Rose
Abstract
Castleman Disease is a rare non-clonal lymphoproliferative disorder that
predisposes towards adults with very few reported cases in children.
Presented is a 12-year-old male with progressive abdominal pain,
vomiting, and fever. Laboratory testing showed elevated inflammatory
markers, hemolysis, kidney injury, coagulopathy, thrombocytopenia, and
refractory hypocalcemia. Imaging demonstrated an adrenal mass,
hepatosplenomegaly, generalized lymphadenopathy, and increased bone
marrow uptake without focality. The diagnosis of Castleman Disease was
made with tissue biopsy and marked disease regression occurred after
high dose steroids and interleukin-6 inhibition. Awareness of Castleman
disease in a pediatric patient is essential to providing adequate and
timely care.