Objectives: The aim of current study was to appraise the relationship between women body image perception and depression in case and controls Methods: In this case-control study 60 polycystic ovarian syndrome patients established agreeing to Rotterdam criteria and 20 healthy controls of reproductive age group were enrolled. The PCOS patients and healthy controls were evaluated on questionnaire for physical appearance and depression. Body image perception was accessed using the validated Body Esteem Scale (Franzoi et al., 1984).The symptoms of Depression were evaluated with the Quick Inventory of Depressive Symptomatology-Self Report (Rush et al., 2003). Results: The groups were age matched therefore no significant disparities were detected (p>0.05). Additionally, significant change (p<0.05) was found of body image perception between cases and controls with vast majority of females declared that they have perceived a positive body image for themselves in both groups which depict a healthy mind frame. However, it was found that controls (those without PCO) were 96% less likely to have negative body image perception as compared to cases (those with PCO). Furthermore, 55% women in PCO group admitted of being depressed as compared to controls as insignificant (p>0.05) association was seen between depression and PCO status of the study subjects. Though PCOS (cases) have 2.27 times more odds to develop depression as compared to those without PCOS Conclusion: There was significant difference found of body image perception between case and controls. In addition, insignificant association was seen between depression and PCO status of study subjects. In addition, the probabilities of negative body image perception and depression were more present in PCOS than normal females. Therefore, health of the patients with the set of symptoms is essential to be acknowledged more fully, predominantly in relation to the despair and poor body image.