Background: Revealing clinical manifestations and associations of COVID-19 before and after negative transition remains an area of significant uncertainty. The aim of this study is to investigate clinical characteristics observed during and after Omicron infection among healthcare workers (HCWs). Methods: From November 4, 2022 to January 15, 2023, HCWs in our hospital were enrolled to document clinical symptoms, prevention, and treatment for COVID-19 using structured questionnaire. Results: Out of the 1101 HCWs included, SARS-CoV-2 infection was detected in 78.20% (861/1101) during observation period. Nucleic acid conversion took a median duration of 8 days. Forty-three symptoms were identified during SARS-CoV-2 infection (11 symptoms per individual). These symptoms can be further categorized into five groups: fever, upper respiratory tract, influenza, digestive, and systemic; all showing complex and diverse patterns. Following SARS-CoV-2 infection, a total of 19 symptoms were recorded including four newly emerged ones: reduced lung capacity, memory loss, lethargy and inattention. Importantly, we observed a significant association between gastrointestinal symptoms during the nucleic acid positive phase and subsequent neuropsychiatric manifestations after negative conversion. Conclusions: The clinical manifestations observed in HCWs during and after Omicron infection displayed intricate patterns, shedding new light on the complex interplay between SARS-CoV-2 and human.

Background and Aims: The DASH diet have been proven to be effective in lowering blood pressure (BP), but it is rarely used in people with type 2 diabetes (T2D), especially in the Chinese population. We aimed to evaluate the effects of 52% low- sodium salt applied to CM-DASH diet in patients with hypertension and T2D. Methods and Results: This trial is a single-blind, randomized controlled study conducted from December 2019 to November 2020 at Chongqing, China. 61 participants were randomly allocated to intervention group or control group for 8 weeks.2 participants were lost, and 59 patients were finally included in the analysis. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) of intervention group and control group were significantly decreased compared with baseline, but there was no difference between groups. The 24-hour urine Na+ and Cl- of the two groups decreased significantly after intervention, but the increase of 24-hour urine K+ and the decrease of Na+/ K+ ratio were only observed in the intervention group. Furthermore,the urine urinary albumin creatinine ratio (UACR) and serum creatinine of two groups also decreased from baseline. Conclusions: Following the CM-DASH diet in hypertensive patients with T2D has beneficial effects in improving SBP and DBP. and the application of 52% low-sodium salt has a significant effect in reducing sodium intake and increasing potassium intake.