Manifestations and outcomes of intracerebral hemorrhage during COVID‐19
pandemic in China: a multicenter, longitudinal cohort study
Abstract
Background: We just right were carrying out a multicenter
cohort study about ICH when COVID-19 broke out in Wuhan,and we wondered
whether COVID-19 pandemic was associated with the manifestations and
outcomes of intracerebral hemorrhage (ICH). Methods: Acute ICH
patients before (1/12/2018-30/11/2019) and during
COVID-19(1/12/2019-30/11/2020) pandemic at 31 centers in China, were
entered into the analysis. Demographic information, clinical
manifestations and outcomes were collected and compared between the two
groups. Results: From December 1, 2018 to November 30, 2020, a
total of 3460 patients with ICH were enrolled and eventually analyzed.
Results showed that patients with ICH were more likely to be older, have
higher systolic blood pressure (BP) (P<0.001), diastolic-BP
(P=0.002), higher admission NIHSS score (P=0.039) and higher fasting
blood glucose (P=0.003) during COVID-19 pandemic compared with before.
After adjusting age, gender, COVID-19 pandemic was associated with
3-month poor outcome (OR adjusted = 1.206, 95%CI:
1.043-1.395) and 3-month mortality (OR adjusted = 1.711,
95%CI: 1.428-2.050) after ICH onset. Conclusions: COVID-19
pandemic deteriorated the manifestations and outcomes of ICH.