Abstract
Objectives: This systematic review summarizes all published uterine
hemangioma cases in pregnant women. Search strategy: The databases
PubMed and Scopus were searched systematically. The reference lists of
all retrieved articles were also screened. Selection criteria: The
online tool Rayyan QCRI was used for registration of the selection
process. Articles reporting on cases of uterine hemangioma in pregnancy
were included, non-English articles were excluded. Data collection and
analysis: Data extraction was done by one reviewer and thereafter
verified by the second reviewer. All data were described in a narrative
format. Results: Fifteen case reports were included. In most cases, the
diagnosis was established by antenatal ultrasound and pregnancy course
was uneventful. More than half of the patients developed a postpartum
hemorrhage, necessitating a hysterectomy for bleeding control in four
cases, although the risk for both seemed lower in those patients in whom
the hemangioma was diagnosed before delivery. One case of maternal
mortality and two cases of fetal death were reported. There was one case
of neonatal respiratory morbidity, although the neonatal data were not
routinely reported upon. Conclusion: Current knowledge on uterine
hemangioma in pregnancy is limited, but it seems to hold substantial
risks for both mother and child. We recommend routine screening for this
condition at the standard mid-trimester anomaly scan. Pregnant women
with uterine hemangioma should ideally be cared for in centers of
expertise. An international registry will help to build a better
understanding of this rare pathology. Funding: None.