The Kenya Long-term Exclosure Experiment (KLEE) was established in 1995 in a semi-arid savanna rangeland on the Laikipia Plateau to examine the separate and combined effects of livestock, wildlife, and megaherbivores (elephants and giraffes) on their shared environment and on each other. The long-term nature of this experiment also allowed us to measure these effects and related questions of stability and resilience in the context of multiple drought-rainy cycles. Here we outline some of the lessons learned over the last 29 years. In particular, we summarize three ways that KLEE exemplifies the value of long-term studies: 1) identifying experimental effects that take a many years to express themselves, 2) quantifying the effects of different years, especially multiple droughts, and 3) capturing time periods long enough to see the signature of systemic, anthropogenic change in the broader landscape. Across all aspects of a long-term study such as this one, there is a need to incorporate both consistency and flexibility to ensure deeper understanding.