Microwave irradiation (MW) and ionic liquids (ILs) are two of the most promising relatively greener synthetic approaches for preparing the value-added chemicals. The breakthrough of their combination in the generation of 2-acylbenzothiazoles is unprecedented and de-sirable. Herein, a series of 2-acylbenzothiazole derivatives were synthesized for the first time from the commercially available α-bromoacetophenones and disulfanediyldianilines under the cooperation of ionic liquids and microwave irradiation, metal- and ex-tra-additives-free conditions. Significantly, the dialkylated [PMIM]I (PMIM = propyl methyl imidazolium) ILs is utilized as the optimal al-ternatives for the cyclization to furnish the 2-acylbenzothiazole and at least reused four times without losing of the reaction activities. Furthermore, thus-obtained products have been further converted to the desired products via Suzuki and Sonogashira reaction. A plausi-ble mechanism involved the successive ILs-induced enolation, radical addition, intramolecular cyclization and MW-induced oxidative dehydrogenation was also proposed. The simplicity and sustainability of MW-assisted ILs-mediated reaction conditions for accessing functionalized benzothiazoles is remarkable and could lead to many synthetic innovations in biologically active molecules.