Association Between Vertigo and Hearing Prognosis in Patients with
Sudden Sensorineural Hearing Loss: a Systematic Review and Meta-analysis
Abstract
ABSTRACT Objective. Our aim was to explore the
relationship between vertigo symptoms and the prognosis of hearing
indicators in patients with sudden sensorineural hearing loss.
Data Source. Eligible studies were identified from the
“PubMed”, “EMBASE”, and “Web of Science” databases from January
2000 to September 2023. Study Selection. Studies were
selected from all original and retrospective or prospective studies that
focused on the relationship between vertigo and hearing prognosis in
patients with sudden sensorineural hearing loss. Data
Extraction and Synthesis. Observational metrics for data extraction
included type of study, number of subjects with or without vertigo,
treatment regimen, definition of pure tone hearing thresholds, criteria
for hearing improvement, treatment duration, follow-up time, and age
distribution of subjects. Meta-analysis was performed using Stata 15
software. Main Outcome and Measure. Association of
vertigo symptoms and the prognosis of hearing indicators in patients
with sudden sensorineural hearing loss. Results.A total
of 4290 patients with sudden sensorineural hearing loss were identified
in 23 studies. The hearing recovery rate was 40.8% in the group with
vertigo and 53.76% in the group without vertigo. Vertigo was
significantly associated with poorer hearing recovery (OR = 2.13; 95%
CI, 1.63-2.79; I 2 = 68.3%). Subgroup analyses
revealed similar results for medication (OR=2.65; 95% CI, 1.84-3.83; I
2 = 50.8%). However, an attenuated association
between vertigo and the prognosis of sudden sensorineural hearing loss
was observed in the subgroups treated with drugs combined with
hyperbaric chambers (OR= 1.76; 95% CI, 0.75-4.15; I 2
= 84.9%) and drugs combined with intratympanic injections (OR= 1.62;
95% CI, 1.02-2.58; I 2 = 65.6%).
Conclusions and Relevance. Our study suggested that
vertigo may be a negative factor in sudden sensorineural hearing
loss.Based on the results of the subgroup analysis,the combined
treatment regimen has better efficacy in patients with sudden
sensorineural hearing loss with vertigo.