High-dose continuous infusion ifosfamide in the treatment of bone marrow
infiltration with severe thrombocytopenia in a patient with Ewing
sarcoma: a case report
Abstract
Ewing sarcoma is a rare primary mesenchymal tumor of the bone that
requires an intensive multimodal therapeutic approach. Multidrug
chemotherapy regimens are also the backbone for relapsing/recurring
Ewing sarcoma treatment, yet when relapse occurs as bone marrow
infiltration, combination chemotherapy might be difficult to be
administered and prognosis is poor. This report describes the case of a
22-year-old patient with Ewing sarcoma who developed severe pancytopenia
due to bone marrow infiltration, who was treated with high-dose
continuous infusion ifosfamide, obtaining both clinical, radiological
and hematological response lasting for about 7 months.