Entropically Secure Encryption (ESE) offers unconditional security with shorter keys compared to the One-Time Pad. In this paper, we present the first implementation of ESE for bulk encryption. The main computational bottleneck for bulk ESE is a multiplication in a very large finite field. This involves multiplication of polynomials followed by modular reduction. We have implemented polynomial multiplication based on the gf2x library, with some modifications that avoid inputs of vastly different length, thus improving speed. Additionally, we have implemented a recently proposed efficient reduction algorithm that works for any polynomial degree. We investigate two use cases: X-ray images of patients and human genome data. We conduct entropy estimation using compression methods whose results determine the key lengths required for ESE. We report running times for all steps of the encryption. We discuss the potential of ESE to be used in conjunction with Quantum Key Distribution (QKD), in order to achieve full information-theoretic security of QKD-protected links for these use cases.