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Yiyue Wang
Public Documents
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Zn-mediated fragmentation of N-alkoxyphthalimides enabling synthesis of gem-difluoroa...
Yiyue Wang
and 4 more
May 27, 2024
Alkoxy radicals have emerged as versatile intermediates to synthesis various organic molecules, and the development of convenient methods for their generation is highly desired. In this work, a new method for the facile access to alkoxy radicals from bench-stable N-alkoxyphthalimides promoted by Zn has been developed for the first time. These alkoxyl radicals subsequently undergo β-scission or hydrogen atom transfer to produce diverse and valuable alkyl radical species, which can be further trapped by α-trifluoromethyl alkenes to construct structurally diverse gem-difluoroalkenes in good yields.