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Palladium/Xu-Phos Catalyzed Enantioselective Intramolecular Heck Reaction of Unactivated Alkenes
  • +2
  • Lujia Zhou,
  • Longling Ma,
  • Bing Xu,
  • Zhan-Ming Zhang,
  • Junliang Zhang
Lujia Zhou
Fudan University
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Longling Ma
Fudan University
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Bing Xu
Fudan University
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Zhan-Ming Zhang
Fudan University

Corresponding Author:[email protected]

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Junliang Zhang
Fudan University
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Abstract

A highly enantioselective palladium-catalyzed intramolecular Heck reaction of unactivated alkenes is developed, which provides a powerful route to access a broad range of chiral 3,3-disubstituted-2,3-dihydrobenzofurans bearing all-carbon quaternary stereocenter of interest in pharmaceutical research. Its salient features include high yield, excellent chemo- and enantioselectivity, mild condi-tions, a broad substrate scope as well as versatile transformations of the product.
16 Apr 2024Submitted to Chinese Journal of Chemistry
18 Apr 2024Submission Checks Completed
18 Apr 2024Assigned to Editor
18 Apr 2024Review(s) Completed, Editorial Evaluation Pending
21 Apr 2024Reviewer(s) Assigned
09 May 2024Editorial Decision: Revise Minor
20 May 20241st Revision Received