Palladium/Xu-Phos Catalyzed Enantioselective Intramolecular Heck
Reaction of Unactivated Alkenes
- Lujia Zhou,
- Longling Ma,
- Bing Xu,
- Zhan-Ming Zhang,
- Junliang Zhang
Abstract
A highly enantioselective palladium-catalyzed intramolecular Heck
reaction of unactivated alkenes is developed, which provides a powerful
route to access a broad range of chiral
3,3-disubstituted-2,3-dihydrobenzofurans bearing all-carbon quaternary
stereocenter of interest in pharmaceutical research. Its salient
features include high yield, excellent chemo- and enantioselectivity,
mild condi-tions, a broad substrate scope as well as versatile
transformations of the product.16 Apr 2024Submitted to Chinese Journal of Chemistry 18 Apr 2024Submission Checks Completed
18 Apr 2024Assigned to Editor
18 Apr 2024Review(s) Completed, Editorial Evaluation Pending
21 Apr 2024Reviewer(s) Assigned
09 May 2024Editorial Decision: Revise Minor
20 May 20241st Revision Received