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Epidemiology of Cholesteatoma in the UK Biobank
  • +3
  • Emma Wilson,
  • Barbara Jennings,
  • Mizanur Khondoker,
  • Carl Philpott,
  • Peter Prinsley,
  • Daniel S. Brewer
Emma Wilson
University of East Anglia Norwich Medical School

Corresponding Author:[email protected]

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Barbara Jennings
University of East Anglia Norwich Medical School
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Mizanur Khondoker
University of East Anglia Norwich Medical School
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Carl Philpott
University of East Anglia Norwich Medical School
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Peter Prinsley
James Paget University Hospitals NHS Foundation Trust
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Daniel S. Brewer
University of East Anglia Norwich Medical School
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Abstract

Level of Evidence: 3 Objective(s) To identify the risk factors for Cholesteatoma in a large UK cohort. Although some risk factors are well established (male sex, history of chronic otitis media), others require further evidence (deprivation, smoking). Design and Setting 1,140 cholesteatoma cases from UK BioBank were compared to 4,551 non-cholesteatoma middle ear disease and 493,832 ear disease-free controls. Adjusted odds ratios were calculated for demographic factors including age, sex, ethnicity, deprivation and smoking status with logistic regressions. Odds ratios for overlapping ICD-10 codes are also calculated. Results Cholesteatoma was significantly associated with sex (Adjusted odds ratio (AOR) for males=1.33), age (AOR=1.02) and deprivation (AOR=1.08) compared to ear disease-free controls ( p<0.001). Age and deprivation distributions for cholesteatoma and non-cholesteatoma ear disease were similar. Although there was no significant association with smoking status, cholesteatoma was significantly associated with the ICD-10 code mental and behavioural disorders due to tobacco use (OR=2.34, p<0.001). Cholesteatoma was also strongly associated with a wide range of inflammatory middle ear conditions and chronic sinus inflammation, suggesting an increased susceptibility to inflammation of the upper airways. Conclusion This study shows a large overlap between cholesteatoma and non-cholesteatoma ear disease in terms of numbers and demographics, with sex being a key factor distinguishing between the two, suggesting that there are both common and distinct risk factors exist.
Submitted to Clinical Otolaryngology
Submission Checks Completed
Assigned to Editor
Reviewer(s) Assigned
30 Aug 2024Review(s) Completed, Editorial Evaluation Pending
01 Sep 2024Editorial Decision: Revise Minor
08 Oct 20241st Revision Received
15 Oct 2024Submission Checks Completed
15 Oct 2024Assigned to Editor
27 Oct 2024Review(s) Completed, Editorial Evaluation Pending
30 Oct 2024Editorial Decision: Accept