Recent Advances in Transition-Metal-Catalyzed Hydrothiolation of Alkenes
to Access Organosulfurs
- Anee Taj,
- Zhen Wang,
- Xiao-Hui Yang
Abstract
The development of new efficient strategies for the construction of the
C-S bond has attracted considerable interest due to its presence in
various crucial biological systems and pharmaceutical compounds. Alkene
hydrothiolation is one of the simplest and most atom-economic methods
for organosulfur synthesis. This review focuses on
transition-metal-catalyzed C-S bond formation via alkene hydrothiolation
with thiols and is divided into three sections covering 3d, 4d, and 5d
transition-metal-catalyzed hydrothiolation re-ported from 2013 to the
present. Synthetic methods, substrate scope, and reaction mechanisms are
discussed. We aim to provide a concise overview of recent advances in
the hydrothiolation of alkenes and hopefully encourage further
exploration to fill the gaps. The current landscape suggests
considerable potential for future innovation and discovery in this
field.Submitted to Chinese Journal of Chemistry Submission Checks Completed
Assigned to Editor
Reviewer(s) Assigned