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Eutypetides A−E, structurally intriguing polyketides forming by Intramolecular [4+2] cycloaddition from the marine-derived fungus Eutypella sp. F0219
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  • Zhongping Jiang,
  • Mengting Chen,
  • Xiao Xiang,
  • Congjun Xu,
  • Yong Rao,
  • Hongzhi Du,
  • Wan-Shan Li,
  • Ling Huang
Zhongping Jiang
Hainan University

Corresponding Author:[email protected]

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Mengting Chen
Hainan University
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Xiao Xiang
Hubei University of Traditional Chinese Medicine
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Congjun Xu
Hainan University
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Yong Rao
Hainan University
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Hongzhi Du
Hubei University of Traditional Chinese Medicine
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Wan-Shan Li
Hainan Normal University
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Ling Huang
Hainan University
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Abstract

Four polycyclic ten-membered lactones possessing unprecedented 10/6/5 tricyclic ring skeleton, named eutypetides A−D (1−4), and an intriguing polyketide containing a hexahydroisobenzofuran-1(3H)-one motif, named eutypetide E (5) were isolated from the ma-rine-derived fungus Eutypella sp. F0219, together with three new related biosynthetic polyketides eutypetides F−H (6−8). The abso-lute configurations of 1−5 were unequivocally determined by single-crystal X-ray diffraction analyses (Cu Kα), and electronic circular dichroism (ECD) calculations. Eutypetides G (7) showed remarkable anti-inflammatory activity and could reduce the mRNA expres-sion of proinflammatory cytokines IL-1β, IL-6, TNF-α, and iNOS induced by LPS. Most notably, compounds 1, 2, and 5 were formed bi-ogenetically from 6−8 via the key intramolecular [4+2] cycloaddition, respectively.
Submitted to Chinese Journal of Chemistry
Submission Checks Completed
Assigned to Editor
Reviewer(s) Assigned
06 Jul 2024Reviewer(s) Assigned
15 Jul 2024Review(s) Completed, Editorial Evaluation Pending
18 Jul 2024Editorial Decision: Revise Minor
13 Aug 20241st Revision Received
15 Aug 2024Submission Checks Completed
15 Aug 2024Assigned to Editor
15 Aug 2024Review(s) Completed, Editorial Evaluation Pending
15 Aug 2024Editorial Decision: Accept