Essential Site Maintenance: Authorea-powered sites will be updated circa 15:00-17:00 Eastern on Tuesday 5 November.
There should be no interruption to normal services, but please contact us at [email protected] in case you face any issues.

loading page

Catalyst-Free C-H Methylation of Heteroarenes Enabled by Electron Donor-Acceptor Complex Photoactivation
  • +4
  • Jiayang Wang,
  • Baoer Shao,
  • Haixia Ge,
  • Huiyu Xue,
  • Xiangyuan Ding,
  • Yuqi Li,
  • Peiyao Sheng
Jiayang Wang
Huzhou University
Author Profile
Baoer Shao
Yuyao People's Hospital

Corresponding Author:[email protected]

Author Profile
Haixia Ge
Huzhou University
Author Profile
Huiyu Xue
Huzhou University
Author Profile
Xiangyuan Ding
Huzhou University
Author Profile
Yuqi Li
Huzhou University
Author Profile
Peiyao Sheng
Huzhou University
Author Profile

Abstract

An efficient, additive- and catalyst -free, visible-light-driven radical C-H methylation of heteroarenes (including quinoxalinones, pyra-zinones, quinolinones and coumarins) utilizing readily available methylamines as the methyl source has been developed. The trans-formation possesses the advantages of operational simplicity, mild reaction conditions and broad substrate scope. Mechanistic studies disclosed that a photoactive electron donor-acceptor (EDA) complex between methylamines and heteroarenes is crucial to this trans-formation.
Submitted to Chinese Journal of Chemistry
Submission Checks Completed
Assigned to Editor
Reviewer(s) Assigned
04 Jul 2024Review(s) Completed, Editorial Evaluation Pending