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Catalyst-Free C-H Methylation of Heteroarenes Enabled by Electron Donor-Acceptor Complex Photoactivation
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  • Jiayang Wang,
  • Baoer Shao,
  • Haixia Ge,
  • Huiyu Xue,
  • Xiangyuan Ding,
  • Yuqi Li,
  • Peiyao Sheng
Jiayang Wang
Huzhou University
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Baoer Shao
Yuyao People's Hospital

Corresponding Author:[email protected]

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Haixia Ge
Huzhou University
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Huiyu Xue
Huzhou University
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Xiangyuan Ding
Huzhou University
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Yuqi Li
Huzhou University
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Peiyao Sheng
Huzhou University
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Abstract

An efficient, additive- and catalyst -free, visible-light-driven radical C-H methylation of heteroarenes (including quinoxalinones, pyra-zinones, quinolinones and coumarins) utilizing readily available methylamines as the methyl source has been developed. The trans-formation possesses the advantages of operational simplicity, mild reaction conditions and broad substrate scope. Mechanistic studies disclosed that a photoactive electron donor-acceptor (EDA) complex between methylamines and heteroarenes is crucial to this trans-formation.
Submitted to Chinese Journal of Chemistry
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04 Jul 2024Review(s) Completed, Editorial Evaluation Pending