Induction of Remission after Donor Lymphocyte Infusion Following
Allogeneic Transplant in a case of Pediatric Primary Myelofibrosis.
Abstract
Pediatric primary myelofibrosis (PMF) is an extremely rare entity which
differs from adult disease in both etiology and outcome.[[1,
2]](https://paperpile.com/c/kO3nmc/v7ZT+LtZX) We report a case of
aggressive primary pediatric myelofibrosis driven by somatic trisomy 8,
JAK2 and SETBP1 mutations. Disease relapsed +45 days post
hematopoietic stem cell transplant. Fortunately, our patient responded
to weaning immunosuppression and donor lymphocyte infusion (DLI) and
remains in remission with only mild liver and skin
graft-versus-host-disease (GVHD). This case is unique not only in its
similarity to adult disease but in the response to DLI as salvage
therapy.