Introduction Collaboration is crucial for innovative scientific contributions, often facilitated through consortia, which are particularly valuable for translating medical innovations to patient care. Despite the rise in consortia, there is limited literature available on how to establish a consortium. This paper aims to provide a comprehensive business and strategy plan for establishing and maintaining biomedical consortia. Methods We explored academic databases and used a snowball sampling method to expand our literature pool, including papers relevant to consortia design such as business and strategy plans. Thematic analysis identified recurring themes, and critical evaluations informed our recommendations, supplemented by experiences from establishing the Neuropsychiatric International Consortium of Frontotemporal Dementia (NIC-FTD). Discussion Our review and experience highlight three key elements for launching and maintaining a successful consortium: (1) Establishment steps and considerations, (2) Consortium agreement and strategy planning, and (3) Maintenance strategies. This paper offers practical guidance for scientists and physicians in establishing and maintaining effective consortia by providing a Consortium Strategy Plan. Conclusion This paper provides a detailed Consortium Strategy Plan with the aim to aid the successful establishment and maintenance of biomedical consortia and to support innovative scientific collaboration.