The rapid advancements in flexible electronics, artificial intelligence (AI), and the Internet of Things (IoT) have made the safe and friendly interaction between humans and machines a significant area of focus. The combination of AI with flexible sensing technology is shown to enhance data processing capabilities, enabling the development of intelligent sensory systems that can analyze and interpret complex sensory data. This review article discusses the integration of artificial intelligence (AI) with flexible sensing technologies to create advanced human-machine interaction (HMI) systems. The design and development of functional materials and innovative structures for building flexible sensor systems are discussed, which are essential for creating intelligent sensory systems that can mimic human senses. This review also explored the applications of intelligent perception systems in various domains, such as visual, auditory, speech, olfactory, gustatory, and tactile perception, demonstrating the potential of these systems in enhancing human-computer interaction. The author emphasizes the challenges and future opportunities in developing AI-driven smart flexible sensor systems, leading to smarter systems capable of environmental ”self-awareness” and opening new avenues in the era of an intelligent society.