COVID-19 is a positive sense, single stranded, enveloped RNA virus having the genomic size of 29.9 kbp. This virus was first observed in Wuhan, China on late December 2019 in a patient who reported the symptoms like viral pneumonia. WHO declared this virus a global health emergency on January 30, 2020. The sign and symptoms of this infection include shortness of breath, dry cough, chest pain, vomiting, nausea, confusion and skin discoloration. SARS-CoV-2 can be transmitted via airborne, droplets and even touching of infected person to non-infected person. There are various risk factors physical as well as mental which are responsible for the infection such as age, gender, area, health facilities, economic status, education status, stress and depression. This review article is about the association between mental health and COVID-19 infection, describes key factors responsible for infection, its mechanism of pathogenicity and association between mental health and the COVID-19 infection.