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Heart failure in long-term survivors of childhood cancer-- A systematic review and meta-analysis of population-based studies
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  • Tove Berg,
  • Jens Böhmer,
  • Bright Nwaru I,
  • Kristjan Karason,
  • Marianne Jarfelt
Tove Berg
Sahlgrenska universitetssjukhuset Drottning Silvias barn- och ungdomssjukhus

Corresponding Author:[email protected]

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Jens Böhmer
Sahlgrenska universitetssjukhuset Drottning Silvias barn- och ungdomssjukhus
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Bright Nwaru I
Goteborgs universitet Institutionen for medicin
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Kristjan Karason
Goteborgs universitet Institutionen for medicin
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Marianne Jarfelt
Goteborgs universitet Institutionen for kliniska vetenskaper
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Abstract

Heart failure (HF) is a common severe non-malignant complication in childhood cancer survivors (CCS). We performed a systematic review to identify, critically appraise and synthesize population-based studies reporting on the incidence and/or prevalence of HF in 5-year CCS (age <18 years). A comprehensive literature search was carried out until March 14 th, 2023, yielding 3883 records, of which four were found eligible. Screening, data extraction, and quality assessment were conducted independently by two reviewers. A meta-analysis of three similar studies found a cumulative incidence of 0.99% (95% CI 0.57–1.42) over 5.0-72.5 years (I-squared=94.4%, p<0.001). Existing population-based studies reporting on HF in 5-year CCS are few and heterogeneous. Further studies are required to enable the development of effective surveillance strategies.