China’s Law on Maternal and Infant Health Care are inadequate for the new context created by the three-child policy, leading to a delay in the provisions of maternal and newborn health (MNH) services. Several provinces have taken the initiative to develop local legislation to improve the local MNH environment. In response to the need for legal reform, Guangdong province in China has made revisions to its Guangdong Province Maternal and Newborn Healthcare Management Regulation (GPMNHMR) The amendments focus on three aspects: enhancing voluntary premarital screening, regulating assisted reproductive technology (ART) practices, and creating a supportive environment for mothers and newborns. Guangdong, having the highest birth rate in China, is one of the provinces with severe birth defects. Therefore, increasing premarital screening rates is essential. Guangdong boasts the highest number of authorized ART institutions in China, requiring effective management. Additionally, inadequate concentration on psychological well-being leads to a high rate of postpartum depression. Incorporating innovative measures into regulations necessitates a comprehensive assessment of their scientific validity and feasibility. Guangdong has advanced legislation through several approaches: integrating effective measures from pilot into regulations; co-decision making, promoting multiple stakeholders to participate in legislation; evidence-based legislation and committing to academic institutions for translation.