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The Effect of Using Perioperative Platelet-Rich Plasma on Wound Healing Rate and Prevention of Salivary Fistula Formation in Patients Undergoing Superficial Parotidectomy
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  • Selim Kul,
  • sema Toros,
  • Çağrı Becerik,
  • Lütfü Şeneldir,
  • Sebahat Aksaray
Selim Kul
TC Saglik Bakanligi Tekirdag Cerkezkoy Ilce Devlet Hastanesi

Corresponding Author:[email protected]

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sema Toros
Istanbul Haydarpasa Numune Egitim ve Arastirma Hastanesi
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Çağrı Becerik
TC Saglik Bakanligi Kemalpasa Devlet Hastanesi
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Lütfü Şeneldir
Istanbul Medipol Universitesi Tip Fakultesi
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Sebahat Aksaray
Istanbul Haydarpasa Numune Egitim ve Arastirma Hastanesi
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Abstract

Objectives: This study aims to examine the effects of autologous platelet-rich plasma (PRP), which increases new connective tissue synthesis and revascularization, on healing in parotid surgery wound, prevention of salivary fistula formation, drain removal time, and hospitalization in the postoperative period. Materials and Methods: Fifty-four patients who had an operation on superficial parotidectomy were randomized, and then two groups were created. PRP was gained by centrifuging the blood taken from the patients at the end of the surgery in the study group. This gained PRP was injected into the surgical site, and then the wound flap was closed by suturing. Patients were evaluated for the parameters such as the development of salivary fistula, duration of drain removal, discharge time, all other complications during the postoperative 4 weeks. Results: Drain removal time and discharge time of the PRP group cases were statistically shorter than those in the control group. The rate of development of salivary fistula according to the groups was remarkably high in the control group, but it was not statistically significant. Statistically significant correlation was found between the location of the compared tumor, and volume of material removed, and the incidence of all complications. Conclusions: PRP reduced the duration of drain removal and discharge time for those who had an operation on superficial parotidectomy. Thus, the decreased discharge time provides both reduced health costs and the risk of developing nosocomial infections. Although it was not statistically significant, a significant difference was observed in the rates of salivary fistula development.
Submitted to Clinical Otolaryngology
04 Jun 2024Review(s) Completed, Editorial Evaluation Pending
08 Jun 2024Editorial Decision: Revise Minor
04 Jul 20241st Revision Received
11 Jul 2024Reviewer(s) Assigned
23 Jul 2024Review(s) Completed, Editorial Evaluation Pending
23 Aug 2024Editorial Decision: Revise Minor
07 Sep 20242nd Revision Received
09 Sep 2024Submission Checks Completed
09 Sep 2024Assigned to Editor
15 Oct 2024Reviewer(s) Assigned
24 Oct 2024Review(s) Completed, Editorial Evaluation Pending