A Study on the Solubility, Dissolution Rate, and Toxicity of Cocrystals
of Bipyridine with Puerarin and Quercetin
Abstract
Abstract: Cocrystallization is emerging as a promising method to enhance
the water solubility of drugs. Puerarin (PUE) and quercetin (QUE)
possess valuable pharmaceutical properties like antioxidant and
antitumor effects but suffer from poor water solubility. To address this
issue, we prepared cocrystals of puerarin-4,4’-bipyridine (PUE-4,4’-BIP)
and quercetin-2,4’-bipyridine (QUE-2,4’-BIP). In artificial gastric
fluid, the solubility and dissolution rates of both puerarin and
quercetin significantly increased after cocrystal formation.
Furthermore, toxicity analysis via LD50 testing revealed lower toxicity
for PUE-4,4’-BIP and QUE-2,4’-BIP cocrystals.