Andrographis saxatilis (Acanthaceae) new species is described and illustrated from the rocky plateau of the Owk Dam area, Andhra Pradesh. It is a perennial, woody undershrub. Unique characters are hispid hairy, obovate, elliptic-oblong and oblanceolate leaves; lanceolate glandular hairy sepals; empty (without flowers) bract and calyx towards base of rachis. Andrographis saxatilis allied A. glandulosa Nees by its perennial habit, woody rootstock in between rocks, glaucous green leaves, hairy stem, attenuate and glandular hairs on sepals and corolla tube outside. But it distinguished from the later by its hispid texture (versus densely pubescent), obovate, elliptic-oblong, and oblanceolate leaves (versus ovate-oblong), obtusely 4-angled stem (versus acutely 4-angled), hispid and glandular hairy sepals (versus villous with long glandular hairs), boat-shaped upper lip of corolla (versus ligulate), pubescent fruit (versus glabrous at base and glandular hairy towards the tip). IUCN threat status of the species is assessed as ‘Data Deficient’ (DD) in this article.