Palladium-Catalyzed Construction of Phthalides Bearing Two Adjacent
Stereocenters through Retro-Oxa-Michael Addition
- Li-Xia Liu,
- Tong Niu,
- Yu-Qing Bai,
- Yong-Gui Zhou
Li-Xia Liu
Dalian Institute of Chemical Physics State Key Laboratory of Catalysis
Author ProfileTong Niu
Dalian Institute of Chemical Physics State Key Laboratory of Catalysis
Author ProfileYu-Qing Bai
Dalian Institute of Chemical Physics State Key Laboratory of Catalysis
Author ProfileAbstract
Optically active phthalides are prevalent in many natural and bioactive
products. Herein, a novel dynamic kinetic resolution of
iso-benzofuranone derivatives through palladium-catalyzed asymmetric
allylic alkylation has been developed to synthesize phthalide
de-rivatives bearing vicinal quaternary and tertiary stereocenters with
high yields, showing excellent regio-, enantio- and
diastereoselec-tivity. Furthermore, gram-scale experiment underwent
smoothly and the transformation of product could build a bridged
bicyclic skeleton.Submitted to Chinese Journal of Chemistry 13 Jun 2024Review(s) Completed, Editorial Evaluation Pending
16 Jun 2024Reviewer(s) Assigned
12 Jul 2024Editorial Decision: Revise Minor
30 Jul 20241st Revision Received
01 Aug 2024Submission Checks Completed
01 Aug 2024Assigned to Editor
01 Aug 2024Review(s) Completed, Editorial Evaluation Pending
01 Aug 2024Editorial Decision: Accept