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Palladium-Catalyzed Construction of Phthalides Bearing Two Adjacent Stereocenters through Retro-Oxa-Michael Addition
  • +1
  • Li-Xia Liu,
  • Tong Niu,
  • Yu-Qing Bai,
  • Yong-Gui Zhou
Li-Xia Liu
Dalian Institute of Chemical Physics State Key Laboratory of Catalysis
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Tong Niu
Dalian Institute of Chemical Physics State Key Laboratory of Catalysis
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Yu-Qing Bai
Dalian Institute of Chemical Physics State Key Laboratory of Catalysis
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Yong-Gui Zhou
Chinese Academy of Sciences Dalian Institute of Chemical Physics

Corresponding Author:[email protected]

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Abstract

Optically active phthalides are prevalent in many natural and bioactive products. Herein, a novel dynamic kinetic resolution of iso-benzofuranone derivatives through palladium-catalyzed asymmetric allylic alkylation has been developed to synthesize phthalide de-rivatives bearing vicinal quaternary and tertiary stereocenters with high yields, showing excellent regio-, enantio- and diastereoselec-tivity. Furthermore, gram-scale experiment underwent smoothly and the transformation of product could build a bridged bicyclic skeleton.
Submitted to Chinese Journal of Chemistry
13 Jun 2024Review(s) Completed, Editorial Evaluation Pending
16 Jun 2024Reviewer(s) Assigned
12 Jul 2024Editorial Decision: Revise Minor
30 Jul 20241st Revision Received
01 Aug 2024Submission Checks Completed
01 Aug 2024Assigned to Editor
01 Aug 2024Review(s) Completed, Editorial Evaluation Pending
01 Aug 2024Editorial Decision: Accept