loading page

Emerging Paradigms: Reimagining Mast Cell Functions in Cutaneous Wound Healing
  • Colin Guth,
  • Nathachit Limjunyawong,
  • Priyanka Pundir
Colin Guth
University of Guelph
Author Profile
Nathachit Limjunyawong
Mahidol University Faculty of Medicine Siriraj Hospital
Author Profile
Priyanka Pundir
University of Guelph

Corresponding Author:[email protected]

Author Profile

Abstract

Chronic wounds significantly burden healthcare systems worldwide, requiring novel strategies to ease their impact. Many physiological processes underlying wound healing are well studied but the role of mast cells is controversial. Mast cells are innate immune cells and play an essential role in barrier function by inducing inflammation to defend the host against chemical irritants, infections, etc. Many mast cell-derived mediators have proposed roles in wound healing; however, in vivo evidence using mouse models has produced conflicting results. Recently, studies involving more complex wound models such as infected wounds, diabetic wounds and wounds healing under psychological stress, suggest that mast cells play critical roles in these processes. This review briefly summarizes the existing literature regarding mast cells in normal wounds and potential reasons for the contradictory results. A focus will be placed on examining more recent work emerging in the last 5 years exploring mast cells in more complex systems of wound healing including infection, psychological stress and diabetes with a discussion of how these discoveries may inspire future work in the field.
11 Jul 2024Submitted to Immunology & Cell Biology
12 Jul 2024Submission Checks Completed
12 Jul 2024Assigned to Editor
15 Jul 2024Reviewer(s) Assigned
11 Sep 2024Review(s) Completed, Editorial Evaluation Pending
12 Sep 2024Editorial Decision: Revise Minor
16 Sep 20241st Revision Received
17 Sep 2024Submission Checks Completed
17 Sep 2024Assigned to Editor
18 Sep 2024Editorial Decision: Accept