Objective The study investigates spatiotemporal trends in rabies incidence, mortality, and DALYs across Indian states and union territories from 1990-2021. It aims to assess current control measures and identify areas needing intervention, informing strategies to achieve zero rabies deaths by 2030. Results India showed significant declining trend over this period for age-standardized incidence rate (AAPC: -5.22; 95%, CI: -5.32 to -5.11; p < 0.05) with the highest decline observed during the period 2007-2010 (APC: -10.12; 95%CI: -10.91 to -8.21; p < 0.05). The highest reductions were observed in Andhra Pradesh (AAPC: -8.08, 95% CI: -8.21 to -7.94), and Bihar (AAPC: -7.10, 95% CI: -7.38 to -6.82). Mortality trends mirrored incidence declines. Total DALYs decreased significantly from 760,115 in 1990 to 12,803 in 2021, primarily due to a reduction in Years of Life Lost (YLL). The age-standardized DALYs per 100,000 persons decreased by -50.22% over the study period. Despite these improvements, rabies remains a critical concern, with 4,023 deaths recorded in 2021. Conclusion Significant declines in rabies incidence, mortality, and DALYs were observed across the time. State-specific multifaceted approach integrating public health, accessible PEP, one health approach and humane management of stray dogs is essential.