Retrospective Perspectives and Future Trends in Nanomedicine Treatment
of Cardiovascular and Cerebrovascular Diseases: From Single Membranes to
Hybrid Membranes
- Xinya Du,
- Junyang Huang,
- Chuanrong Zhao,
- Ziqiu Hu,
- Liyuan Zhang,
- Zichen Xu,
- Xiaoying Liu,
- Xinglei Li,
- Songtao Guo,
- Tieying Yin,
- Guixue Wang
Abstract
At present, cardiovascular and cerebrovascular diseases seriously
threaten human life and health, and the development of nanodrug delivery
systems has brought about a turnaround for traditional drug treatments,
with nanoparticles being precisely targeted to improve bioavailability.
In addition, surface modification of nanoparticles can prolong blood
circulation time and enhance targeting ability. The application of cell
membrane-coated nanoparticles further improves their biocompatibility
and active targeting ability, providing new hope for the treatment of
cardiovascular and cerebrovascular diseases. In recent years, various
types of cell membrane biomimetic nanoparticles have gradually attracted
increasing attention due to their unique advantages. However, the
single-cell membrane has several limitations because a single functional
property cannot fully meet the requirements of cardiovascular and
cerebrovascular disease treatment. Hybrid cell membranes integrate the
advantages of multiple biological membranes and have become an emerging
research hotspot. This review summarizes the application of single-cell
membrane biomimetic nanoparticles in the treatment of cardiovascular and
cerebrovascular diseases and discusses the advantages, challenges and
future development of biomimetic nanoparticles. We propose that the
fusion of multiple membranes may be a reasonable trend in the future to
provide some ideas and directions for the treatment of cardiovascular
and cerebrovascular diseases.