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Prevalence of Frequent Premature Ventricular Contractions and Left-ventricular systolic dysfunction In Patients Receiving Holter Monitoring
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  • Juan Torrado,
  • Adam Sima,
  • Connor Comstuck,
  • Karoly Kaszala,
  • Alex Tan,
  • Jayanthi Koneru,
  • David Frankel,
  • Francis E. Marchlinski,
  • Marcin Kowalski,
  • Parikshit Sharma,
  • Edward Gerstenfeld,
  • Marmar Vaseghi,
  • Kalyanam Shivkumar,
  • Rohit Malhotra,
  • Carlos A. Morillo,
  • Kenneth Ellenbogen,
  • Jose Huizar
Juan Torrado
Virginia Commonwealth University Division of Cardiology
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Adam Sima
Virginia Commonwealth University Division of Cardiology
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Connor Comstuck
Virginia Commonwealth University Division of Cardiology
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Karoly Kaszala
Virginia Commonwealth University Division of Cardiology
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Alex Tan
Virginia Commonwealth University Division of Cardiology
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Jayanthi Koneru
Virginia Commonwealth University Division of Cardiology
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David Frankel
University of Pennsylvania Perelman School of Medicine
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Francis E. Marchlinski
University of Pennsylvania Perelman School of Medicine
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Marcin Kowalski
Staten Island University Hospital
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Parikshit Sharma
Rush University Medical Center
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Edward Gerstenfeld
UCSF Medical Center
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Marmar Vaseghi
University of California Los Angeles Heart and Vascular Services
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Kalyanam Shivkumar
University of California Los Angeles Heart and Vascular Services
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Rohit Malhotra
UVA Health University Hospital
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Carlos A. Morillo
Libin Cardiovascular Institute of Alberta
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Kenneth Ellenbogen
Virginia Commonwealth University Division of Cardiology
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Jose Huizar
Virginia Commonwealth University Division of Cardiology

Corresponding Author:[email protected]

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Abstract

Background: Premature ventricular contractions (PVCs) are frequently observed with left ventricular (LV) systolic dysfunction, although the prevalence of these associated conditions in the general population remains unknown. Objective: We sought to understand the prevalence of frequent PVCs (defined PVCs>5%) and high burden PVCs (defined PVCs>10%) and LV systolic dysfunction in patients receiving ambulatory Holter monitors (HM). Methods: A prospective multicenter (8 US medical centers) cross-sectional study collected demographic and PVC burden data from consecutive patients undergoing 24-hour, 48-hour, and 14-day HM (July 2018-June 2020). Left ventricle ejection fraction (LVEF) data was collected if obtained within 6 months of HM. Four PVC burden groups were analyzed (<1%, 1-5%, 5.1-10% and >10% burden) and stratified by normal LVEF (≥50%) or presence LVEF<50%. Results: The prevalence of PVC burden of 5.1-10% and >10% was 4% and 5%, respectively in the population undergoing HM (n=6,529). Age was significantly different between PVC groups (p<0.001). In those with LVEF assessment (n=3,713), the prevalence of LVEF<50% and both LVEF<50% and PVC>5% was 16.4% and 4.2%, respectively. The prevalence of PVC>5% and PVC>10% in patients with LVEF<50% was 26% and 16%, respectively. PVC>5% were more prevalent in older, male, and Caucasians (p<0.001). Females had a lower prevalence of PVC>5% than males (6% vs. 11%; p<0.001), but not among those with LVEF<50% (24% vs. 26%, p=0.10). Conclusion: PVC>5% and PVC>10% and LVEF<50% are prevalent in patients undergoing HM. PVC>5% are associated with older age. Females have a lower prevalence of PVC>5% than males but similar combined PVC>5% and LVEF<50%.
30 Jul 2024Submitted to Journal of Cardiovascular Electrophysiology
01 Aug 2024Review(s) Completed, Editorial Evaluation Pending
01 Aug 2024Submission Checks Completed
01 Aug 2024Assigned to Editor
03 Aug 2024Reviewer(s) Assigned
02 Sep 2024Editorial Decision: Revise Minor
04 Oct 20241st Revision Received
08 Oct 2024Submission Checks Completed
08 Oct 2024Assigned to Editor
08 Oct 2024Review(s) Completed, Editorial Evaluation Pending
13 Oct 2024Editorial Decision: Accept