IntroductionThe incidence of abdominal wall endometriosis has shown a rising trend, yet malignant transformation of abdominal wall endometriosis remains rare. Literature from both domestic and international sources reports that the incidence of malignant transformation in endometriosis is around 1%, with approximately 80% of endometriosis-related malignancies occurring in the ovaries. The remaining 20% occur outside the ovaries, with only 0.9% occurring at abdominal scar sites[1]. The mechanism of its development is not yet clear. This article reports on a case of clear cell carcinoma of abdominal wall endometriosis and its high-throughput genetic testing results, while also reviewing relevant literature to discuss this disease.