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Dual-Site Beta tACS over the rIFG and preSMA Induced Phase-Specific Changes in Functional Connectivity but Not Response Inhibition Performance in Older Adults
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  • Jane Tan,
  • Kartik Iyer,
  • Michael A Nitsche,
  • Rohan Puri,
  • Mark Hinder,
  • Hakuei Fujiyama
Jane Tan
Murdoch University

Corresponding Author:[email protected]

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Kartik Iyer
QIMR Berghofer Medical Research Institute
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Michael A Nitsche
Leibniz-Institut fur Arbeitsforschung an der TU Dortmund
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Rohan Puri
University of Tasmania
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Mark Hinder
University of Tasmania
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Hakuei Fujiyama
Murdoch University
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Abstract

Research suggests that changes in functional connectivity contribute to age-related declines in response inhibition. Through a double-blind crossover study, we investigated the effects of dual-site beta transcranial alternating current stimulation (tACS) over the right inferior frontal gyrus (rIFG) and pre-supplementary motor area (preSMA) on functional connectivity measured with electroencephalography and response inhibition (stop-signal task performance) in 15 older (aged 61-79 years) and 18 young (aged 18-34 years) adults. Two tACS conditions were administered in separate sessions: in-phase tACS, where electrical currents delivered to rIFG and preSMA had a 0° phase difference, and anti-phase tACS, where currents had a 180° phase difference. Resting-state beta band rIFG-preSMA connectivity significantly increased after in-phase tACS for older and young adults, and decreased after anti-phase tACS for older adults. This shows that tACS can modulate rIFG-preSMA connectivity in a phase-specific manner in the aging brain. However, response inhibition significantly improved after both in- and anti-phase tACS for young and older adults, indicating that inhibitory performance might not be directly regulated by resting-state rIFG-preSMA phase connectivity.
15 Aug 2024Submitted to Psychophysiology
16 Aug 2024Submission Checks Completed
16 Aug 2024Assigned to Editor
16 Aug 2024Review(s) Completed, Editorial Evaluation Pending
26 Aug 2024Reviewer(s) Assigned
23 Oct 2024Editorial Decision: Revise Minor
29 Oct 20241st Revision Received
29 Oct 2024Submission Checks Completed
29 Oct 2024Assigned to Editor
29 Oct 2024Review(s) Completed, Editorial Evaluation Pending
04 Nov 2024Reviewer(s) Assigned