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Plant Protein Farming, a valuable tool in the production of
cost-effective and stable biopharmaceuticals: an overview.
Abstract
Protein farming, or molecular farming, is an innovative approach that
utilizes plants/animals/microorganisms as biofactories to produce
valuable pharmaceutical proteins, antibodies, vaccines, and other
high-value bio-active molecules. This emerging field has gained
significant attention due to its potential to address the growing demand
for affordable and scalable biopharmaceutical production platform.
Correspondingly, plants offer several advantages over traditional
expression systems, including low production costs, scalability, ease of
manipulation, and reduced risk of contamination by pathogens. This
review provides an overview of principles underlying protein farming in
plants (P-farm), including the identification and selection of host,
optimization of transgene expression, and downstream processing
techniques for protein purification. It also discusses recent
advancements in plant biotechnology and the development of transient
expression systems to use genetically modified plants (transgenic
plants) in the enhancement of protein production. Additionally, the
potential applications and challenges associated with molecular farming
in plants are considered, including prospects of commercialization and
novel opportunities to meet the growing demands of global healthcare
markets.