Among the many adverse geological disasters, the surge water disaster in karst area causes the greatest damage to underground engineering construction, so there is an urgent need to carry out relevant research on the management of surge water disaster in karst pipeline. However, the grouting material in the blocking process of karst surge water disaster often has the problems of low retention and low blocking efficiency. In order to improve the efficiency of dynamic groundwater plugging in karst area, a new type of cement-water glass slurry was developed by taking ordinary silicate cement as the base material and adding water glass to get cement-water glass slurry, and then using polyacrylamide, Fe ₃O ₄ magnetic powder, xanthan gum and guar gum as the additives. The response surface regression model was constructed by Design-Expert software to analyse the effects of the four admixtures, namely, polyacrylamide, Fe ₃O ₄ magnetic powder, xanthan gum and guar gum, on the setting time, retention rate and compressive strength of the new type of cement-water glass slurry, and combined with the craving function to obtain the optimal proportioning of the new type of cement-water glass slurry. The results show that: the interaction of each two admixtures has a significant effect on the setting time of the slurry; while xanthan gum and Fe ₃O ₄ magnetic powder have a significant effect on the retention rate of the slurry as a single factor; the effect of single factor on the compressive strength of the slurry is more significant, and the polyacrylamide admixture has the greatest effect.The model predicts the optimal ratios: 0.6% polyacrylamide, 0.7% of xanthan gum, 0.4% of guar gum, and 29.96% of Fe ₃O ₄ powder, which can be used as a reference for the multi-objective optimisation of the mixing ratio of the new type of cement-water glass slurry.