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A Case of Primary Cutaneous Marginal Zone Lymphoma in a 12-year-old with Mast Cell Activating Syndrome
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  • Madison Wnuk,
  • Marjorie Montanez-Wiscovich,
  • Sthorn Thatayatikom,
  • William Slayton
Madison Wnuk
University of Florida College of Medicine
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Marjorie Montanez-Wiscovich
University of Florida College of Medicine
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Sthorn Thatayatikom
Advent Health Orlando
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William Slayton
University of Florida College of Medicine

Corresponding Author:[email protected]

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Abstract

Primary cutaneous marginal zone lymphoma (PCMZL) is reported to primarily affect non-Hispanic Caucasian males over 50 years old. We present a case of a 16-year-old female with mast cell activation syndrome (MCAS) who developed PCMZL of the skin of both cheeks, left forearm and right arm. The patient was treated initially with intralesional steroids which successfully shrunk lesions on her face and left forearm. Rituximab and doxycycline were attempted but stopped due to severe allergic reactions and anaphylaxis. Ultimately, the remaining nodules on her right arm were surgically excised.