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Multifunctional biopolymer hydrogels containing carrier-free bioactive-loaded microcapsules for S. aureus-infected wound healing
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  • Mianhong Chen,
  • Jiaqi Li,
  • Xiaobing Huang,
  • Jizhen Zhang,
  • David Julian McClements,
  • Kefeng Wu,
  • Yunxia He,
  • Ruyi Li,
  • Jihua Li,
  • Wei Zhou
Mianhong Chen
Agricultural Products Processing Research Institute Chinese Academy of Tropical Agricultural Sciences
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Jiaqi Li
Agricultural Products Processing Research Institute Chinese Academy of Tropical Agricultural Sciences
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Xiaobing Huang
Agricultural Products Processing Research Institute Chinese Academy of Tropical Agricultural Sciences
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Jizhen Zhang
Institute for Frontier Materials
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David Julian McClements
University of Massachusetts Amherst Department of Food Science
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Kefeng Wu
Guangdong Medical University Key Laboratory for Natural Drug Research and Development of Guangdong Province
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Yunxia He
Agricultural Products Processing Research Institute Chinese Academy of Tropical Agricultural Sciences
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Ruyi Li
Agricultural Products Processing Research Institute Chinese Academy of Tropical Agricultural Sciences
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Jihua Li
Agricultural Products Processing Research Institute Chinese Academy of Tropical Agricultural Sciences
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Wei Zhou
Agricultural Products Processing Research Institute Chinese Academy of Tropical Agricultural Sciences

Corresponding Author:[email protected]

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Abstract

Wound healing dressings are designed to accelerate the regeneration of skin tissue and return it to its normal physiological activity. Several factors must be considered when designing wound healing dressings, including their mechanical, barrier, adhesive, degradation, and safety properties, as well as their ability to promote tissue regeneration. In this study, natural active small molecule anisaldehyde-tannic acid-zinc ion (AA-TA-Zn 2+) microcapsules by self-assembly and coordination strategies without any carrier or surfactant are constructed, integrating good antimicrobial, antioxidant, anti-inflammatory activities, sustained release, and pH responsiveness. Subsequently, natural small-molecule microcapsules are used to functionalize chitosan-gelatin (CG)-based hydrogels, endowing them with good injectability, adhesion, self-healing, antibacterial, antioxidant, and anti-inflammatory properties. This multifunctional hydrogel is primarily formed through a fourfold cross-linking mechanism involving Schiff base formation, hydrogen bonding, ionic interactions, and electrostatic forces, without the involvement of any chemical synthesis reactions. The microcapsules-loaded hydrogels are shown to kill bacteria around the wound, reduce oxidative stress damage, inhibit the proliferation of inflammatory cells, facilitate the reconstruction of the vascular network, promote the orderly deposition of collagen, facilitate the reconstruction of damaged tissues, clean the micro-environment of the wound areas, and recover the normal immune system, thereby hastening the repair and healing of S. aureus-infected wounds. These advanced multifunctional dressings may therefore have great potential for application in the biomedical field.