Background: The clinical presentation of COVID-19 varies widely, ranging from asymptomatic cases to multisystemic failures, driving the scientific community to explore biochemical markers that could aid in early diagnosis, management, and the prevention of possible complications. Objective: This study is focused on identifying any significant trends or patterns in the demographic and biochemical characteristics of the deceased individuals, providing valuable insights into the factors that contribute to COVID-19-related deaths. Methodology: A cross-sectional research study was conducted at a tertiary care facility, involving 121 COVID-19 deaths that were recorded at the hospital between June 12, 2020, and May 22, 2021. The data were collected using a structured proforma to record demographic parameters such as age, sex, and number of days from symptom onset to death, as well as biochemical markers and analyzed using SPSS version 26.0. Result: Among the 121 deceased individuals, 76 (62.8%) were male, with a mean age of 60.14±14.87 years. The average duration from symptom onset to death was 10.76±6.73 days. The majority of the sample had high levels of D-dimer 73(82.02%), CRP 81(95.29%) and ferritin levels 83(95.40%). Additionally, a high neutrophil count was found in 69(65.71%), while 47(44.76%) exhibited a low lymphocyte count. Conclusion: Elevated levels of D-dimer, CRP, and other plasma markers have been found to poor outcomes in COVID-19 patients, indicating the importance of monitoring these parameters in clinical practice Early detection and intervention through a combination of demographic, biochemical, clinical, and radiological indicators can help prevent the worst outcomes and improve patient outcomes.