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Determination of the Yearly Distribution of the Incidence of Allergic Bronchopulmonary Aspergillosis (ABPA) in Patients Registered in the Cystic Fibrosis Patient Registry System of Turkey and Identification of Risk Factors for its Development
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  • Havva İpek Demir,
  • Ebru Yalcin (Guest Editor),
  • Halime Nayir Buyuksahin,
  • Suat Savaş,
  • Velat Şen,
  • Hadice Selimoglu Sen,
  • Azer Kılıç Başkan,
  • Ayse Ayzit Kilinc,
  • Hakan Yazan,
  • Abdulhamit Çollak,
  • Erkan Çakır,
  • Hanife Tuğçe Çağlar,
  • Fatih Ercan,
  • Sevgi Pekcan,
  • Merve Korkmaz,
  • Yakup Canitez,
  • Bahar Girgin Dindar,
  • Figen Gülen,
  • elif arik,
  • Özlem Keskin,
  • Ali Ersoy,
  • Mehmet KOSE,
  • Mahir Serbes,
  • Derya Altıntaş,
  • Ebru Damadoğlu,
  • Oğuz Karcıoğlu,
  • Abdurrahman Erdem Başaran,
  • Ayşen Bingöl,
  • Zeynep İlkşen Hocoğlu,
  • Ayşe Aslan,
  • Demet Polat Yuluğ,
  • Ali Özdemir,
  • Işıl Bilgiç,
  • Gokcen Tugcu,
  • koray harmanci,
  • Beste Ozsezen,
  • Pervin Korkmaz,
  • Nazan Cobanoglu (Guest Editor),
  • Hasan Yüksel,
  • Sibel Doğru,
  • Gönül Çaltepe,
  • Melih Hangul,
  • Zeynep Gayretli Aydın,
  • Mehmet KILIC,
  • Hamza Ogun,
  • Mina Hizal,
  • Ayşe Süleyman,
  • Gizem Ozcan,
  • Aslı Görek Dilektaşlı,
  • Tugba Sismanlar-Eyuboglu,
  • Nagehan Emiralioglu,
  • Guzin Cinel,
  • ugur ozcelik,
  • Deniz Dogru
Havva İpek Demir
Hacettepe Universitesi Tip Fakultesi

Corresponding Author:[email protected]

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Ebru Yalcin (Guest Editor)
Hacettepe Universitesi Tip Fakultesi
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Halime Nayir Buyuksahin
Hacettepe Universitesi Tip Fakultesi
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Suat Savaş
Dicle Universitesi Tip Fakultesi
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Velat Şen
Dicle Universitesi Tip Fakultesi
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Hadice Selimoglu Sen
Dicle Universitesi Tip Fakultesi
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Azer Kılıç Başkan
Istanbul Universitesi-Cerrahpasa Cerrahpasa Tip Fakultesi
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Ayse Ayzit Kilinc
Istanbul Universitesi-Cerrahpasa Cerrahpasa Tip Fakultesi
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Hakan Yazan
Bezmialem Vakif Universitesi Tip Fakultesi
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Abdulhamit Çollak
Bezmialem Vakif Universitesi Tip Fakultesi
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Erkan Çakır
Istinye Universitesi
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Hanife Tuğçe Çağlar
Necmettin Erbakan Universitesi Tip Fakultesi
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Fatih Ercan
Necmettin Erbakan Universitesi Tip Fakultesi
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Sevgi Pekcan
Necmettin Erbakan Universitesi Tip Fakultesi
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Merve Korkmaz
Bursa Uludag Universitesi Tip Fakultesi
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Yakup Canitez
Bursa Uludag Universitesi Tip Fakultesi
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Bahar Girgin Dindar
Ege Universitesi Tip Fakultesi
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Figen Gülen
Ege Universitesi Tip Fakultesi
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elif arik
Gaziantep Universitesi Tip Fakultesi
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Özlem Keskin
Gaziantep Universitesi Tip Fakultesi
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Ali Ersoy
Erciyes Universitesi Tip Fakultesi
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Mehmet KOSE
Erciyes Universitesi Tip Fakultesi
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Mahir Serbes
Cukurova Universitesi Tip Fakultesi
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Derya Altıntaş
Cukurova Universitesi Tip Fakultesi
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Ebru Damadoğlu
Hacettepe Universitesi Tip Fakultesi
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Oğuz Karcıoğlu
Hacettepe Universitesi Tip Fakultesi
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Abdurrahman Erdem Başaran
Akdeniz Universitesi Tip Fakultesi
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Ayşen Bingöl
Akdeniz Universitesi Tip Fakultesi
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Zeynep İlkşen Hocoğlu
Gazi Universitesi Tip Fakultesi
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Ayşe Aslan
Gazi Universitesi Tip Fakultesi
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Demet Polat Yuluğ
TC Saglik Bakanligi Mersin Sehir Egitim ve Arastirma Hastanesi
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Ali Özdemir
TC Saglik Bakanligi Mersin Sehir Egitim ve Arastirma Hastanesi
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Işıl Bilgiç
Ankara Sehir Hastanesi Cocuk Hastanesi
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Gokcen Tugcu
Ankara Sehir Hastanesi Cocuk Hastanesi
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koray harmanci
Eskisehir Osmangazi Universitesi Tip Fakultesi
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Beste Ozsezen
TC Saglik Bakanligi Sanliurfa Egitim ve Arastirma Hastanesi
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Pervin Korkmaz
Ege Universitesi Tip Fakultesi
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Nazan Cobanoglu (Guest Editor)
Ankara Universitesi Tip Fakultesi
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Hasan Yüksel
Manisa Celal Bayar Universitesi
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Sibel Doğru
Gaziantep Universitesi Tip Fakultesi
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Gönül Çaltepe
Ondokuz Mayis Universitesi Tip Fakultesi
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Melih Hangul
TC Saglik Bakanligi Gaziantep Cengiz Gokcek Kadin Dogum ve Cocuk Hastaliklari Hastanesi
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Zeynep Gayretli Aydın
Karadeniz Teknik Universitesi Tip Fakultesi
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Mehmet KILIC
Firat Universitesi Hastanesi
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Hamza Ogun
Bezmialem Vakif Universitesi Tip Fakultesi
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Mina Hizal
SBU Ankara Dr Sami Ulus Kadin Dogum Cocuk Sagligi ve Hastaliklari Egitim ve Arastirma Hastanesi
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Ayşe Süleyman
Istanbul Universitesi Istanbul Tip Fakultesi
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Gizem Ozcan
Kayseri Sehir Egitim ve Arastirma Hastanesi
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Aslı Görek Dilektaşlı
Bursa Uludag Universitesi Tip Fakultesi
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Tugba Sismanlar-Eyuboglu
Gazi Universitesi Tip Fakultesi
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Nagehan Emiralioglu
Hacettepe Universitesi Tip Fakultesi
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Guzin Cinel
Ankara Sehir Hastanesi Cocuk Hastanesi
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ugur ozcelik
Hacettepe Universitesi Tip Fakultesi
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Deniz Dogru
Hacettepe Universitesi Tip Fakultesi
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Abstract

not-yet-known not-yet-known not-yet-known unknown Background: Allergic bronchopulmonary aspergillosis (ABPA), which is one of the respiratory complications of cystic fibrosis, is a hypersensitivity reaction in the lung against the antigens of the fungus Aspergillus fumigatus ( A.fumigatus). If left untreated, it may cause irreversible deteriorations in lung functions. The aim of this study is to determine the incidence of ABPA, according to years and to determine the risk factors leading to the development of ABPA by using the CF Registry System of Turkey data. Methods: The study was designed as a retrospective cohort study. Using the CF Registry System of Turkey data, the incidence of ABPA was determined and the data of 44 patients newly diagnosed with ABPA in 2022 and 132 patients with similar mutation weight and age range without ABPA diagnosis in that year were compared, and the risk factors affecting the development of ABPA were determined. Results: Low pulmonary function test values, having had at least one pulmonary exacerbation in that year and receiving intravenous antibiotic treatment, using inhaled antibiotics, having a high number of pulmonary exacerbations, having Pseudomonas aeroginosa (P.aeroginosa) colonization, having a low body mass index (BMI) and having cystic fibrosis related diabetes mellitus (CFRD) were found to be among the risk factors for the development of ABPA. Conclusions: Early recognition and treatment of ABPA is essential to prevent further damage to the lungs. Patients with frequent pulmonary exacerbations, low BMI and low pulmonary function test values, chronic colonization should definitely be considered for ABPA.