The texture, structure, and micromechanics of sandstones control natural and man-made processes throughout the Earth’s upper crust. Until now, these features have been studied primarily through a combination of 2D optical and electron microscopy, 3D X-ray tomography, and mechanical loading experiments. Here, we demonstrate application of multiple in-situ X-ray probes which together provide the most complete 3D picture to-date of a sandstone specimen’s texture, structure, and micromechanics before and during mechanical loading. The X-ray probes we employ include near-field high-energy diffraction microscopy (nf-HEDM), X-ray computed tomography (XRCT), and far-field high-energy diffraction microscopy (ff-HEDM). nf-HEDM, applied prior to mechanical loading of the specimen, revealed crystal orientations and 3D spatially-resolved intra-granular misorientations, suggesting the formation of grain overgrowths with orientations both aligned and misaligned with seeding grains. XRCT, performed in-situ before and throughout loading, revealed a growing fracture network oriented orthogonal to the loading direction, suggesting the presence of columnar force-chain-like structures. ff-HEDM, also performed in-situ before and throughout loading, provided average elastic grain stress tensors and confirmed the increasingly vertical alignment of principal compressive stresses and emergence of force-chain-like structures prior to failure. Our results provide the first-known application of these three X-ray probes to sandstone and demonstrate their potential to elucidate key attributes of these materials, such as their propensity to feature force-chain-like structures previously observed in granular materials but only hypothesized to exist in rocks.