National goals frequently require transdisciplinary or multisectoral science and policy coordination, making them challenging to achieve. The One Health approach is designed to coordinate and communicate science and policy across multisectoral and transdisciplinary challenges by integrating science and policy for the human, animal, plant, and environmental health sectors. This approach is expanding to address a larger spectrum of societal, economic, national security, and environmental challenges. The Science and Technology Policy Institute (STPI) asked if the application of a One Health approach would improve our ability to achieve national goals.