Background and purpose: Ischemic stroke in one of the leading causes of acquired disability worldwide. While studies on left atrial function as a risk factor for stroke have been conducted, data on right atrium and right ventricle function are scant. The present study aims to compare the left and right atria and the right ventricle echocardiographic indices between anterior (ACI) and posterior (PCI) circulation stroke patients. Methods: This cross-sectional study enrolled 102 patients with confirmed anterior or posterior ischemic stroke between 2022 and 2024. Baseline characteristics, clinical and laboratory data were obtained and 2-dimensional transthoracic echocardiography was performed for all patients. Differences between the two stroke groups were investigated. Results: ACI patients had significantly higher National institute of health stroke scores (NIHSS) and right ventricular fractional area change was significantly higher in PCI patients ( P-value=0.036 and 0.005 respectively). Among initial laboratory data aspartate aminotransferase and C-reactive protein levels were significantly different between the two groups ( P-value=0.022 and 0.025, respectively). Aortic annulus (aortic AA), aortic stenosis junction (aortic STJ) and pulmonary artery mean pressure gradient (PA MG) were also significantly different among two groups (P-value= 0.002, 0.016 and 0.006 respectively). Conclusions: Our findings suggest that patients with ACI may have a slightly different pattern of right ventricular remodeling compared to patients with PCI, which may be associated with differences in cardiac structure and function.