Background: Migraine is a multifactorial disorder in which headaches usually last from 4 to 72 hours. Sphenopalatine ganglion blockage (SPGB) has been used as a minimal invasive method for alleviating pain in severe headaches. Aim: We discuss our technique of performing SPGB and assessment of pain relief, before and after its application. We have also made an effort to study the prevalence of depression and quality of life by scoring patients of chronic migraine and assess how SPGB helps to reduce the incidence of depression and quality of life. Material and methods: Observational and interventional clinical study. Pain scores were recorded using the numeric rating score (NRS) prior to and 15 minutes after SPGB. Patients were also assessed for prevalence of depression and quality of life – based on 2 questionnaires (PHQ-9 and WHO-5) – before and 2 weeks after performing SPGB. Results: After intervention by SPGB, there was a statistically significant (p value <0.001) reduction of pain, the mean scores reduced from 7.41 +/- 2 to 2.02 +/- 1.57. Improvement in quality of life and a statistically significant reduction of depression scores after intervention were seen. The prevalence of depression significantly decreased after SPGB. Conclusion: SPGB is a minimally invasive, effective, focused and practical treatment for migraines. Improved quality of life and likelihood of reduction of depressive symptoms after SPGB will also alter the overall well-being of these patients.