The human metabolism evolved under conditions of scarcity—finely tuned for whole foods, intermittent fasting, and rare glucose surges. The modern diet—dominated by ultra-processed foods and relentless carbohydrate exposure—overwhelms this system, forcing it into continuous metabolic stress. The question is not why metabolic disease is rising, but why we would expect anything else.

When any system is forced beyond its tolerances, failure is inevitable. The biological consequences—obesity, type 2 diabetes, fatty liver disease, cardiovascular disorders, neurodegeneration—are not separate conditions. They are the same failure state manifesting in different tissues, at different speeds.

This paper exposes how modern diets systematically override metabolic regulation, pushing the body into a state of perpetual dysregulation. It dismantles the myth that these conditions are personal failings or genetic inevitabilities. They are not anomalies—they are engineered outcomes.

This paper is Part 2 of a three-part series. Part 1, The Chronic Crisis, details the structural incentives driving the modern health crisis. Part 3, Metabolic Eating, presents the necessary correction—how to realign nutrition with biological function to prevent systemic metabolic failure.