With the escalating global prevalence of obesity, understanding eating behavior is an imperative focus of research. Emerging evidence underscores the central role of dopamine and its receptors in normal and pathological regulation of food intake. Investigations have confirmed the stimulatory effect of selective activation of D4 dopamine receptors within the paraventricular nucleus of the hypothalamus on food intake. This leads to the hypothesis that perturbations in hypothalamic dopaminergic signaling pathways that regulate energy homeostasis may potentially underlie the propensity for obesity-related excess caloric consumption via a D4 Receptor-mediated mechanism. This study aims to elucidate the effects of central administration of the D4 receptor antagonist, L-745,870, on regulating food intake, satiety, and locomotor activity. Here, we investigated the impact of intra-paraventricular blockade of D4 receptors on standard food consumption, behavioral satiety sequence, and locomotor activity in male Wistar rats. Our results indicate that injection of L-745,870 at doses of 0.1 and 1 µg induces a significant reduction in standard food intake within sixty minutes of administration. At a dose of 0.1 µg, L-745,870 accelerated the onset of postprandial satiety without a significant effect on locomotor activity. Together, our results highlight the central role of D4 receptors in the modulation of feeding behavior and satiety and provide a potential avenue for using this compound for the development of pharmacological interventions for obesity. The demonstrated efficacy of L-745,870 in reducing food intake supports its potential therapeutic utility in the broader context of obesity management.