Avoiding Atrioesophageal Fistula Formation after Atrial Fibrillation
Ablation -- Preventive Measures and Newer Ablative Technology
Abstract
Atrial esophageal fistula (AEF) is a rare but life-threatening
complication of atrial fibrillation (AF) ablation, linked to thermal
injuries by conventional radiofrequency (RF) and cryo-balloon (CB)
ablation techniques. AEF risk can be mitigated by considering several
measures such as monitoring esophageal luminal temperature, tailored
power settings of ablation technique, mechanical displacement of
esophagus, esophageal cooling, and alternative ablative techniques and
energy sources. We review the current knowledge regarding AEF and
esophageal thermal injuries as well as discussing the current research
regarding a novel non-thermal, myocardial tissue-selective modality
known as pulsed-field ablation (PFA) which may mitigate such risks. By
inducing irreversible electroporation, PFA reduces thermal injury and
demonstrates improved safety profiles, as evidenced by recent
meta-analyses reporting zero esophageal injury and AEF cases.
Additionally, the integration of 3D mapping systems with PFA has
enhanced its procedural precision and accuracy as well as the ability to
utilize real-time imaging. Despite these advances, challenges such as
standardizing anesthesia protocols and tailoring energy settings remain.
Our review suggests that PFA may reduce the risk of AEF from catheter
ablation of AF. Although PFA may reduce the risk of any aberrant thermal
injuries, studies report increased incidences of coronary vasospasms and
hemolysis. Future long-term outcome studies should provide more
information on possible adverse outcomes with PFA as well as tailoring
the power settings of PFA.